CCR2 Signal Facilitates Thymic Egress by Priming Thymocyte Responses to Sphingosine-1-Phosphate

CCR2 Signal Facilitates Thymic Egress by Priming Thymocyte Responses to Sphingosine-1-Phosphate

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The signal mediated by sphingosine-1-phosphate receptor 1 (S1P1) is essential but seemingly insufficient for thymic export of newly generated T cells.Here, we reported the identification of CCR2 as an additional regulator of this process.CCR2 showed a markedly Flywheel Pulley increased expression in the most mature subset of single-positive (SP) thymocytes.

Its deficiency led to a reduction of recent thymic emigrants in the periphery and a simultaneous accumulation of mature SP cells in the thymus.The CCR2 signaling promoted thymic emigration primarily through modulating the chemotactic responses to S1P1 engagement.On the one hand, the Football - Gloves - Senior chemokinesis induced by CCR2 activation endowed thymocytes with enhanced capacity to respond to S1P-induced migration.

On the other hand, CCR2 signaling through Stat3 augmented forkhead box O1 activity, leading to increased expression of S1P1.Taken together, the present study highlights a unique and novel function of CCR2 signaling in the regulation of thymic egress.